HORDB

General Information

ID: hor006740
Uniprot ID: P58294(20-105)
Protein name: Prokineticin-1
Gene name: PROK1
Organism: Homo sapiens (Human)
Family: AVIT (prokineticin) family
Source: Human
Expression: In adult testis, is strongly expressed only in Leydig cells. In testicular tumors, expressed specifically in Leydig cell tumors (at protein level). Expressed from 14 weeks until birth in fetal testis.|Localizes to glandular epithelium, stroma and vascular
Disease: Diseases associated with PROK1 include Neuroblastoma and Endocervicitis.
Comments: NA
Taxonomy: Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0008083 growth factor activity
GO BP: GO:0001525 angiogenesis; GO:0001935 endothelial cell proliferation; GO:0007165 signal transduction; GO:0008283 cell population proliferation; GO:0043410 positive regulation of MAPK cascade; GO:0045765 regulation of angiogenesis; GO:0051781 positive regulation of cell division; GO:0101023 vascular endothelial cell proliferation; GO:1905564 positive regulation of vascular endothelial cell proliferation
GO CC: GO:0005576 extracellular region

Sequence Information

Sequence: AVITGACERDVQCGAGTCCAISLWLRGLRMCTPLGREGEECHPGSHKVPFFRKRKHHTCPCLPNLLCSRFPDGRYRCSMDLKNINF
Length: 86(20-105)
Propeptide: MRGATRVSIMLLLVTVSDCAVITGACERDVQCGAGTCCAISLWLRGLRMCTPLGREGEECHPGSHKVPFFRKRKHHTCPCLPNLLCSRFPDGRYRCSMDLKNINF
Signal peptide: MRGATRVSIMLLLVTVSDC
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Activity

Function: Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of oth
Mechanism: NA
Cross BBB: NA
Target: PROKR2
Target Unid: Q8NFJ6
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: 7-19; 13-31; 18-59; 41-67; 61-77
Structure ID: AF-P58294-F1(AlphaFold_DB_ID)

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006740_AF2.pdb

hor006740_ESM.pdb

Physical Information

Mass:	1118365	Formula:	C414H660N130O114S12
Absent amino acids:		Common amino acids:	CR
pI:	8.58	Basic residues:	17
Polar residues:	30	Hydrophobic residues:	23
Hydrophobicity:	-28.72	Boman Index:	-16525
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	64.65
Instability Index:	5125.23	Extinction Coefficient cystines:	7615
Absorbance 280nm:	89.59

Literature

PubMed ID: 11259612
Title: Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle.
PubMed ID: 11528470
Title: Identification of an angiogenic mitogen selective for endocrine gland endothelium.
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large
PubMed ID: 16710414
Title:
PubMed ID: 15489334
Title:
PubMed ID: 15340161
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PubMed ID: 15292351
Title:
PubMed ID: 17289879
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PubMed ID: 18339712
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